Adding acetaminophen to ibuprofen sodium dihydrate for pain control

A randomized double-blind study published in the Journal of Endodontics compared the pain reduction potential of single-dose ibuprofen sodium dihydrate alone with that of single-dose ibuprofen sodium dihydrate plus acetaminophen combination in an acute endodontic pain model of untreated patients experiencing moderate to severe pain owing to symptomatic apical periodontitis.

In the study, 64 adult emergency patients in acute moderate to serve pain, a plural diagnosis of symptomatic irreversible pulpits or necrosis, and symptomatic apical periodontitis participated. The data were analyzed statistically. 

This small (n=64 adults) study in an emergency room setting found that ibuprofen sodium dihydrate alone was effective and that the addition of acetaminophen did not appear to be necessary.

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