Can high blood pressure promote scar healing?
Investigators have analyzed the relationship between high blood pressure, wound healing and pathological scarring.
Previous research has suggested that high blood pressure may promote pathological scar formation through mechanisms such as extracellular matrix imbalance, inflammation-induced hypoxia and elevated angiotensin II levels.
In a study, published in Frontiers in Medicine, the investigators used genetic variants as instrumental variables to explore the causal relationship between blood pressure and keloids and hypertrophic scars.
The investigators found that high blood pressure was associated with a lower risk of keloids and hypertrophic scars. They hypothesized that increases in blood pressure may enhance blood flow to certain areas of the skin, thereby boosting oxygen supply and increasing wound healing.
Despite the positive findings, the investigators emphasized the need for further studies validating the results and exploring potential clinical implications for blood pressure management in patients at risk of pathological scarring.
Read more: Frontiers in Medicine
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