Can polyphenolic compounds reduce hypersensitivity and allergy symptoms?

A systematic review and meta-analysis published in the Journal of Allergy and Clinical Immunology evaluated the clinical effectiveness of polyphenolic compounds — such as catechins, quercetin and apple polyphenol — in managing allergic rhinitis. 

Analyzing 13 randomized controlled trials with 823 participants, the study found that polyphenolic compounds significantly alleviated nasal symptoms in seasonal allergic rhinitis, including total nasal symptom scores, sneezing, and nasal itching. The review found that in perennial allergic rhinitis, while overall nasal symptom scores improved, effects on individual symptoms were inconsistent. 

A pooled analysis and sensitivity analysis excluding outlier studies revealed moderate improvements in total nasal symptoms, nasal obstruction, and sneezing across both allergic rhinitis types. However, the overall certainty of evidence was rated low to very low due to heterogeneity and methodological limitations. No significant improvements were observed in quality of life, according to the review. 

Read more: JACI 

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