Combination treatment could help reduce biofilm
The addition of the sesquiterpene zerumbone to antimicrobial photodynamic therapy could be effective at managing treatment-resistant fungal infections.
In a study published in the Journal of Dentistry, researchers analyzed the effects of several treatment combinations against fluconazole-resistant and -susceptible Candida albicans biofilms and fluconazole-resistant clinical isolates: zerumbone alone or zerumbone in combination with a photosensitizer or light-emitting diode.
The researchers found that zerumbone plus antimicrobial photodynamic therapy resulted in more effective treatment of biofilms for all strains of C. albicans; greater reductions in colony-forming unit counts, total biomass, insoluble biomass and total protein; decreases in extracellular matrix components of the biofilms and higher content of dead cells.
The findings indicated that zerumbone in combination with antimicrobial photodynamic therapy may be an effective antifungal treatment option in patients with fluconazole-resistant C. albicans.
Read more: Journal of Dentistry
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