Comparing topical treatments in atopic dermatitis

A study explored the effectiveness of topical treatments in atopic dermatitis.

In the network meta-analysis, published in JAMA Dermatology, investigators analyzed data from 291 clinical trials involving nearly 46,000 patients with atopic dermatitis who were treated with topical anti-inflammatory agents.

The investigators found that potent and very potent topical corticosteroids, tacrolimus 0.1% and Janus kinase inhibitors demonstrated the greatest symptom relief in the short-term treatment of atopic dermatitis. However, mild corticosteroids and phosphodiesterase-4 inhibitors like crisaborole and roflumilast were the least effective treatment options.

Despite the findings, the analysis was limited to short-term randomized trials. The investigators emphasized that longer-term, real-world studies could help better understand which topical treatments are most effective in patients with atopic dermatitis.

Read more: JAMA Dermatology

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