Does low testosterone increase risk of mortality?

Investigators have discovered a surprising link between low testosterone levels and increased mortality risk in men, according to a study published in the Annals of Internal Medicine.

The investigators performed a systematic literature review to identify prospective cohort studies that included data on testosterone, sex hormone-binding globulin, luteinizing hormone, dihydrotestosterone and estradiol concentrations — as well as all-cause mortality, cardiovascular disease-related mortality and incident cardiovascular disease events.

The investigators found that the men who had baseline testosterone concentrations lower than 7.4 nanomoles per liter, luteinizing hormone higher than 10 international units per liter and estradiol concentrations lower than 5.1 picomoles per liter were more likely to experience all-cause mortality. Men with testosterone concentrations below 5.3 nanomoles per liter had a higher likelihood of experiencing cardiovascular disease-related mortality.

Read more: Annals of Internal Medicine

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