Endodontic therapy could reduce cardiometabolic risks

Successful endodontic treatment could enhance cardiometabolic health.

In a study published in the Journal of Translational Medicine, researchers examined metabolic and inflammatory biomarkers following root canal treatment, root canal retreatment or periapical surgery in 65 patients with apical periodontitis. They used nuclear magnetic resonance spectroscopy to examine the patients’ blood samples at baseline prior to treatment as well as at three, six, 12 and 24 months posttreatment.

The researchers observed changes in 24 metabolites, demonstrating improvements in glycemic control and lipid metabolism as well as reductions in inflammatory biomarkers following successful root canal therapy. For instance, they identified notable decreases in glucose and pyruvate and short-term decreases in cholesterol, choline and fatty acid levels.

The findings suggested that positive outcomes following endodontic treatment could influence systemic inflammation and mitigate the risk of cardiometabolic disorders in patients with apical periodontitis.

Read more: Journal of Translational Medicine

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