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Heightened risk of Parkinson’s disease in patients with certain gastrointestinal conditions

Gastrointestinal factors may indicate an increased risk of developing Parkinson’s disease.

In a study published in JAMA Network Open, investigators analyzed the data of 9,350 patients with no prior history of Parkinson’s disease who underwent upper endoscopy between 2000 and 2005.

The investigators identified a significant association between upper gastrointestinal mucosal damage and the risk of Parkinson’s disease. For instance, those who had erosions, esophagitis, ulcers or peptic injury in their upper gastrointestinal tract had a 76% increased risk of later developing Parkinson’s disease compared with those who didn’t present with any mucosal damage during endoscopy.

Further, the patients who experienced constipation or dysphagia or were older in age had an elevated risk of developing Parkinson’s disease.

The findings suggested that physicians should monitor patients with upper gastrointestinal mucosal damage for signs of Parkinson’s disease.

Read more: JAMA Network Open

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