Illuminating postpreservation properties of dental pulp-derived stem cells

Although dental pulp-derived stem cells have shown efficacy in regenerative and immunomodulatory treatments, there is still uncertainty regarding the cells’ survival following long-term cryopreservation.

In a study published in the Journal of Endodontics, researchers assessed the viability, immunophenotype, proliferation, stemness and senescence of dental pulp-derived stem cells collected from 12 patients after the cells were preserved for either five, 10 or 13 years.

The researchers found over 90% expression of stem cell markers and less than 4% expression of hematopoietic markers. Further, they reported that the cells demonstrated multipotency and a resistance to senescence. There were no statistically significant differences in proliferative capacity between the five-, 10- and 13-year cryopreservation groups.

The findings highlighted the potential benefits of developing biobanks for the long-term preservation of dental pulp-derived stem cells without compromising their therapeutic efficacy.

Read more: Journal of Endodontics

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