Illuminating side effects from injectable soft tissue fillers

Investigators may have uncovered oral reactions to injectable soft tissue fillers.

In a study published in Oral Diseases, the investigators used data from eight pathology laboratories to analyze the oral and perioral reactions to injectable soft tissue fillers among 151 patients — a majority of whom were female. The most common types of fillers were silicone, polymethylmetacrylate and hyaluronic acid.

The investigators found that the most prevalent reaction presented as asymptomatic nodules. Multinucleated giant cells, foamy macrophages and granulomas occurred in about 65.3%, 51.5% and 44% of the patients, respectively. Further, the reactions appeared most frequently in the upper lip, buccal mucosa and lower vestibule.

The investigators underscored the importance of considering oral reactions to injectable soft tissue fillers when examining asymptomatic submucosal nodules, particularly among female patients.

Read more: Oral Diseases

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