Is IBS genetically linked to certain cardiovascular diseases?

Researchers may have identified genetic links between irritable bowel syndrome and cardiovascular disease.

In a comprehensive genome-wide association study, published in Cellular and Molecular Gastroenterology and Hepatology, the researchers used the UK Biobank and Lifelines cohorts to examine the genetic correlations between three IBS subtypes and cardiovascular disease among more than 24,000 patients with IBS and 77,000 controls.

The investigators discovered that IBS and IBS-mixed type shared genetic loci with hypertension and coronary artery disease — highlighting genes involved in circadian rhythm, intestinal barrier function, immunomodulation and the cyclic adenosine monophosphate pathway.

There was also a correlation between IBS-constipation type and angina pectoris and chronic ischemic heart disease. Further, compared with controls, the patients with IBS were more likely to have anxiety disorders and dyspepsia.

Further studies may be needed to better understand the genetic association between IBS and cardiovascular disease.

Read more: Cellular and Molecular Gastroenterology and Hepatology

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