Peri-implantitis biomarkers uncovered
Newly identified biomarkers could help clinicians diagnose and treat patients with peri-implantitis.
Although both peri-implantitis and periodontitis have overlapping treatment approaches, differences in the pathogenesis of the conditions have remained little understood.
In a study published in the Journal of Dentistry, researchers collected and sequenced RNA from the gingival tissue samples of patients with peri-implantitis and periodontitis with the hopes of elucidating the underlying genetic, immunologic and physiologic factors associated with both conditions.
The researchers discovered a critical link between peri-implantitis and activated fibroblasts, which proliferate in patients with the condition. Further, they found that three genes — ACTA2, FAP and PDGFR-beta — may be overexpressed in peri-implantitis but not periodontitis.
The researchers hope their findings may establish disease-specific indicators for peri-implantitis for the more accurate diagnoses, targeted treatments and durable dental implants.
Read more: Journal of Dentistry
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