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Regenerative endodontic procedures: Minced pulp tissue grafts

A study has explored the outcomes and factors impacting regenerative endodontic procedures with minced pulp tissue grafts in mature permanent teeth.

In the study, published in the Journal of Endodontics, researchers introduced autologous minced pulp tissue from third molars into the instrumented, disinfected and blood-filled root canals of six patients aged 20 to 27 years undergoing nonsurgical root canal treatment. They then sealed the root canal and restored the access cavity.

After follow-ups of 19 to 42 months, the researchers observed favorable radiographic outcomes among all of the teeth. They detailed that two of the teeth showed no intracanal calcification or recovery in sensibility tests, two teeth showed intracanal calcification in the apical third but no recovery in the sensibility tests, one tooth showed no intracanal calcification and an inapplicable sensibility test, and one tooth showed intracanal calcification in the apical third and recovery in sensibility tests. The researchers reported the size of the apical foramen and the composition of the transplanted pulp tissue as factors impacting posttreatment outcomes.

The researchers hope their findings can provide insights into regenerative endodontic procedures and demonstrate the therapy’s potential as an alternative to conventional endodontic treatment.

Read more: Journal of Endodontics

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