Relationship between neighborhood environment, prostate cancer
Investigators have examined whether neighborhood deprivation may impact the risk of developing prostate cancer.
In a study published in JAMA Network Open, the investigators analyzed the outcomes of 1,469 men — 736 of whom were Black and 733 of whom were white — who resided in the greater Baltimore area between 2005 and 2016. They included both prostate cancer cases and controls without the disease.
The investigators found that the men with West African ancestry residing in highly deprived neighborhoods were significantly more likely to develop prostate cancer compared with the men with West African ancestry who resided in less deprived areas. Further, West African ancestry was more prevalent in the Black patients with prostate cancer compared with the Black controls without the disease. After adjusting for the Neighborhood Deprivation Index, the investigators discovered an inverse association between West African ancestry and the risk of prostate cancer and a statistically insignificant risk of all-cause mortality.
The findings indicated that neighborhood environments may be a key factor in defining how genetic ancestry influences the risk of prostate cancer in this patient population.
Read more: JAMA Network Open
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