Relationship between vitamin D supplementation, cardiometabolic risk factors

Using vitamin D supplements could improve cardiometabolic risk factors, but the effects could vary depending on demographic and clinical characteristics.

In a meta-analysis published in Engineering, investigators examined the impact of vitamin D supplementation on blood pressure, blood lipids and glycemic parameters in 17,656 patients across 99 randomized controlled trials. They used the PubMed, Web of Science and Embase databases to identify the trials published up to March 26, 2024.

Vitamin D supplements were found to reduce systolic blood pressure, diastolic blood pressure, total cholesterol levels, fasting blood glucose levels, hemoglobin A1C and fasting blood insulin. However, non-Western participants demonstrated greater improvements in glycemic parameters compared with Western participants, those with a lower body mass index showed greater improvements in systolic blood pressure and glycemic parameters, and participants with older age experienced greater improvements in outcomes. Further, higher vitamin D doses and longer intervention durations benefited certain cardiometabolic risk factors.

The investigators concluded that personalized interventions may be needed to tailor treatment strategies to meet individual patient needs.

Read more: Engineering

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