Sex-based differences in post-heart attack mortality risk identified

Investigators have uncovered the factors that could impact long-term outcomes among patients with acute myocardial infarction.

In a retrospective study published in The Lancet Regional Health-Europe, investigators used data from the Myocardial Ischaemia National Audit Project to analyze the outcomes of more than 930,000 patients hospitalized for acute myocardial infarction between 2005 and 2019. The participants were divided into four groups on the basis of their post-myocardial infarction frailty: fit, mild, moderate or severe.

The investigators found that frailty was more prevalent among female patients compared with male patients. However, male patients with severe frailty were more likely to experience all-cause mortality at one year compared with female patients with severe frailty.

As a result of the findings, the investigators emphasized the need for more sex-based risk assessment and care strategies to inform the most effective treatment options among all patients with acute myocardial infarction.

Read more: The Lancet Regional Health-Europe

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