Shorter course of antibiotics in bloodstream infections

A one-week antibiotic regimen may be comparable to a two-week regimen in treating Gram-negative bloodstream infections.

In a systematic review and meta-analysis published in JAMA Network Open, the investigators used the PubMed, Cochrane Central Register of Controlled Trials and Web of Science databases to identify randomized clinical trials focused on adult patients hospitalized for Gram-negative bloodstream infections between May 1, 2022, and Nov. 30, 2024. They examined the data of four trials involving 3,729 patients.

After assessing 90-day mortality rates, the investigators found that the one-week antibiotic regimen had a 97.8% likelihood of being noninferior to the two-week regimen. The results suggested that a shorter antibiotic regimen may be effective among appropriately selected patients.

Read more: JAMA Network Open

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